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Beta thalassemia gene therapy using lentiviral vectors
Recent years, allogeneic bone marrow transplantation (BMT) has proved to be the successful cure for patients with thalassemia major, however this is restricted due to limited matched-related donor. Its complications include chronic graft-versus-host disease in 5-8% of patients. So, a molecular approach, such as gene therapy for direct normal beta globin gene transmission, seems quite promising ...
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ژورنال
عنوان ژورنال: Journal of Physics A: Mathematical and General
سال: 2005
ISSN: 0305-4470,1361-6447
DOI: 10.1088/0305-4470/38/7/013